The role of breast-feeding in infant immune system: a systems perspective on the intestinal microbiome.

ABSTRACT:

Background

The human intestinal microbiota changes from being sparsely populated and variable to possessing a mature, adult-like stable microbiome during the first 2 years of life. This assembly process of the microbiota can lead to either negative or positive effects on health, depending on the colonization sequence and diet. An integrative study on the diet, the microbiota, and genomic activity at the transcriptomic level may give an insight into the role of diet in shaping the human/microbiome relationship. This study aims at better understanding the effects of microbial community and feeding mode (breast-fed and formula-fed) on the immune system, by comparing intestinal metagenomic and transcriptomic data from breast-fed and formula-fed babies.

Results

We re-analyzed a p

SUBMITTER: Praveen P 

PROVIDER: S-EPMC4581423 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature