Genome-wide association study identifies SNPs in the MHC class II loci that are associated with self-reported history of whooping cough.

ABSTRACT: Whooping cough is currently seeing resurgence in countries despite high vaccine coverage. There is considerable variation in subject-specific response to infection and vaccine efficacy, but little is known about the role of human genetics. We carried out a case-control genome-wide association study of adult or parent-reported history of whooping cough in two cohorts from the UK: the ALSPAC cohort and the 1958 British Birth Cohort (815/758 cases and 6341/4308 controls, respectively). We also imputed HLA alleles using dense SNP data in the MHC region and carried out gene-based and gene-set tests of association and estimated the amount of additive genetic variation explained by common SNPs. We observed a novel association at SNPs in the MHC class II region in both cohorts [lead SNP rs9271768

SUBMITTER: McMahon G 

PROVIDER: S-EPMC4581602 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature