Predicting Carriers of Ongoing Selective Sweeps without Knowledge of the Favored Allele.

ABSTRACT: Methods for detecting the genomic signatures of natural selection have been heavily studied, and they have been successful in identifying many selective sweeps. For most of these sweeps, the favored allele remains unknown, making it difficult to distinguish carriers of the sweep from non-carriers. In an ongoing selective sweep, carriers of the favored allele are likely to contain a future most recent common ancestor. Therefore, identifying them may prove useful in predicting the evolutionary trajectory--for example, in contexts involving drug-resistant pathogen strains or cancer subclones. The main contribution of this paper is the development and analysis of a new statistic, the Haplotype Allele Frequency (HAF) score. The HAF score, assigned to individual haplotypes in a sample, naturally

SUBMITTER: Ronen R 

PROVIDER: S-EPMC4581834 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature