Release of Small RNA-containing Exosome-like Vesicles from the Human Filarial Parasite Brugia malayi.

ABSTRACT: Lymphatic filariasis (LF) is a socio-economically devastating mosquito-borne Neglected Tropical Disease caused by parasitic filarial nematodes. The interaction between the parasite and host, both mosquito and human, during infection, development and persistence is dynamic and delicately balanced. Manipulation of this interface to the detriment of the parasite is a promising potential avenue to develop disease therapies but is prevented by our very limited understanding of the host-parasite relationship. Exosomes are bioactive small vesicles (30-120 nm) secreted by a wide range of cell types and involved in a wide range of physiological processes. Here, we report the identification and partial characterization of exosome-like vesicles (ELVs) released from the infective L3 stage of the human

SUBMITTER: Zamanian M 

PROVIDER: S-EPMC4581865 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature