Benefits of Systemic Anti-inflammatory Therapy versus Fluocinolone Acetonide Intraocular Implant for Intermediate Uveitis, Posterior Uveitis, and Panuveitis: Fifty-four-Month Results of the Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study.

ABSTRACT:

Purpose

To compare the benefits of fluocinolone acetonide implant therapy versus systemic corticosteroid therapy supplemented (when indicated) with immunosuppression for intermediate uveitis, posterior uveitis, and panuveitis.

Design

Additional follow-up of a randomized comparative effectiveness trial cohort.

Participants

Two hundred fifty-five patients with intermediate uveitis, posterior uveitis, or panuveitis randomized to implant or systemic therapy.

Main outcome measures

Best-corrected visual acuity (BCVA), visual field mean deviation (MD), activity of uveitis, and presence of macular edema (per reading center grading) ascertained prospectively.

Methods

Trial participants were followed-up for 54 months from original randomization.

Results

The

SUBMITTER: Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group 

PROVIDER: S-EPMC4581989 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature