Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction.

ABSTRACT: Sepsis is an infection-induced severe inflammatory disorder that leads to multiple organ failure. Amongst organs affected, myocardial depression is believed to be a major contributor to septic death. While it has been identified that large amounts of circulating pro-inflammatory cytokines are culprit for triggering cardiac dysfunction in sepsis, the underlying mechanisms remain obscure. Additionally, recent studies have shown that exosomes released from bacteria-infected macrophages are pro-inflammatory. Hence, we examined in this study whether blocking the generation of exosomes would be protective against sepsis-induced inflammatory response and cardiac dysfunction. To this end, we pre-treated RAW264.7 macrophages with GW4869, an inhibitor of exosome biogenesis/release, followed by endot

SUBMITTER: Essandoh K 

PROVIDER: S-EPMC4581992 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature