Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells.

ABSTRACT: Environmental factors contribute to the development of autoimmune diseases, including systemic lupus erythematosus (SLE), which exhibits a strong female bias (female-to-male ratio 9:1). However, the molecular mechanisms remain largely unknown. Because a feedforward loop between the female sex hormone estrogen (E2) and type I interferon (IFN-α/β)-signaling induces the expression of certain p200-family proteins (such as murine p202 and human IFI16) that regulate innate immune responses and modify lupus susceptibility, we investigated whether treatment of myeloid cells with bisphenol A (BPA), an environmental estrogen, could regulate the p200-family proteins and activate innate immune responses. We found that treatment of murine bone marrow-derived cells (BMCs) and human peripheral blood mono

SUBMITTER: Panchanathan R 

PROVIDER: S-EPMC4581997 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature