Structure-Based Design of Dendritic Peptide Bolaamphiphiles for siRNA Delivery.

ABSTRACT: Development of safe and effective delivery vectors is a critical challenge for the application of RNA interference (RNAi)-based biotechnologies. In this study we show the rational design of a series of novel dendritic peptide bolaamphiphile vectors that demonstrate high efficiency for the delivery of small interfering RNA (siRNA) while exhibiting low cytotoxicity and hemolytic activity. Systematic investigation into structure-property relationships revealed an important correlation between molecular design, self-assembled nanostructure, and biological activity. The unique bolaamphiphile architecture proved a key factor for improved complex stability and transfection efficiency. The optimal vector contains a fluorocarbon core and exhibited enhanced delivery efficiency to a variety of cell l

SUBMITTER: Zeng H 

PROVIDER: S-EPMC4582325 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature