Multigene Molecular Profiling in Nasopharyngeal Carcinoma: A Case of Monozygotic Twins

ABSTRACT:

Introduction:

Nasopharyngeal carcinoma (NPC) is an epithelial tumor with high incidence in southern China and Southeast Asia. Oncogene mutation patterns in NPC have yet to be fully elucidated. It is also unclear if the inheritance of oncogene mutations contribute to the development of NPC. Using a multigene cancer exome sequencing panel, we sought to investigate oncogenes that were shared between both NPCs that developed in a pair of monozygotic female twins. We also examined these patterns, in the context of germline variants found in their unaffected brother.

Case Summary:

Twin A was first diagnosed with Stage I poorly differentiated NPC in 1988 and underwent radiation therapy with complete remission. Her cancer relapsed in 1991 as lung metastasis. She underwent left th

SUBMITTER:  

PROVIDER: S-EPMC4582378 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature