Transcriptional changes induced by candidate malaria vaccines and correlation with protection against malaria in a human challenge model.

ABSTRACT:

Introduction

The complexity of immunity to malaria is well known, and clear correlates of protection against malaria have not been established. A better understanding of immune markers induced by candidate malaria vaccines would greatly enhance vaccine development, immunogenicity monitoring and estimation of vaccine efficacy in the field. We have previously reported complete or partial efficacy against experimental sporozoite challenge by several vaccine regimens in healthy malaria-naïve subjects in Oxford. These include a prime-boost regimen with RTS,S/AS02A and modified vaccinia virus Ankara (MVA) expressing the CSP antigen, and a DNA-prime, MVA-boost regimen expressing the ME TRAP antigens. Using samples from these trials we performed transcriptional profiling, allowing a global

SUBMITTER: Dunachie S 

PROVIDER: S-EPMC4582771 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature