Contrasting the Genetic Background of Type 1 Diabetes and Celiac Disease Autoimmunity.

ABSTRACT: Type 1 diabetes (T1D) and celiac disease (CeD) cluster in families and can occur in the same individual. Genetic loci have been associated with susceptibility to both diseases. Our aim was to explore the genetic differences between individuals developing both these diseases (double autoimmunity) versus those with only one. We hypothesized that double autoimmunity individuals carry more of the genetic risk markers that are shared between the two diseases independently. SNPs were genotyped in loci associated with T1D (n=42) and CeD (n=28) in 543 subjects who developed double autoimmunity, 2,472 subjects with T1D only, and 2,223 CeD-only subjects. For identification of loci that were specifically associated with individuals developing double autoimmunity, two association analyses were conduct

SUBMITTER: Gutierrez-Achury J 

PROVIDER: S-EPMC4582914 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature