Cytokine Concentrations in Plasma from Children with Severe and Non-Severe Community Acquired Pneumonia.

ABSTRACT:

Background

Children in low and middle-income countries have a high burden of pneumonia. Measuring the cytokine responses may be useful to identify novel markers for diagnosing, monitoring, and treating pneumonia.

Objective

To describe and compare a wide range of inflammatory mediators in plasma from children with WHO-defined severe and non-severe community acquired pneumonia (CAP), and explore to what extent certain mediators are associated with severity and viral detection.

Methods

We collected blood samples from 430 children with severe (n = 43) and non-severe (n = 387) CAP. Plasma from these children were analysed for 27 different cytokines, and we measured the association with age, disease severity and viral detection.

Results

There were generally higher pl

SUBMITTER: Haugen J 

PROVIDER: S-EPMC4583304 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature