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Association of the Functional MICA-129 Polymorphism With the Severity of Chronic Chagas Heart Disease.

ABSTRACT: MICA-129 polymorphism affects the binding affinity of MICA molecules with the NKG2D receptor and influences effector cell function. The genotype met/met was associated with the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas heart disease, while the val/val genotype was associated with the absence of LVSD.

SUBMITTER: Ayo CM 

PROVIDER: S-EPMC4583584 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Association of the Functional MICA-129 Polymorphism With the Severity of Chronic Chagas Heart Disease.

Ayo Christiane Maria CM   Oliveira Amanda Priscila de AP   Camargo Ana Vitória da Silveira AV   Mattos Cinara Cássia Brandão de CC   Bestetti Reinaldo Bulgarelli RB   Mattos Luiz Carlos de LC  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20150630 8

MICA-129 polymorphism affects the binding affinity of MICA molecules with the NKG2D receptor and influences effector cell function. The genotype met/met was associated with the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas heart disease, while the val/val genotype was associated with the absence of LVSD. ...[more]

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