Effect of Beta-Blocker Dose on Survival After Acute Myocardial Infarction.

ABSTRACT:

Background

Beta-blocker therapy after acute myocardial infarction (MI) improves survival. Beta-blocker doses used in clinical practice are often substantially lower than those used in the randomized trials establishing their efficacy.

Objectives

This study evaluated the association of beta-blocker dose with survival after acute MI, hypothesizing that higher dose beta-blocker therapy will be associated with increased survival.

Methods

A multicenter registry enrolled 7,057 consecutive patients with acute MI. Discharge beta-blocker dose was indexed to the target beta-blocker doses used in randomized clinical trials, grouped as >0% to 12.5%, >12.5% to 25%, >25% to 50%, and >50% of target dose. Follow-up vital status was assessed, with the primary endpoint of time-to-death

SUBMITTER: Goldberger JJ 

PROVIDER: S-EPMC4583654 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature