Pedigree-Free Descent-Based Gene Mapping from Population Samples.

ABSTRACT: Segments of the genome inherited from a common ancestor by related individuals are said to be identical by descent (IBD). Modern genetic marker data provide information to infer such segments among multiple related members of a population, even when pedigree relationships are unknown. Previous methods have been proposed for the detection of pairwise IBD, but the computation of probabilities of trait data under many trait models requires an IBD estimate jointly consistent among individuals and slowly varying across genome locations; we refer to such an estimate as an 'IBD graph'. In this paper, we develop a novel method that builds IBD graphs sequentially among related individuals from a population sample using either phased or unphased genetic marker data. We show how IBD graphs realized c

SUBMITTER: Glazner C 

PROVIDER: S-EPMC4583811 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature