Gene expression profiling by high throughput sequencing to determine signatures for the bovine receptive uterus at early gestation.

ABSTRACT: The uterus plays a central role among the reproductive tissues in the context of early embryo-maternal communication and a successful pregnancy depends on a complex series of endometrial molecular and cellular events. The factors responsible for the initial interaction between maternal and embryonic tissues, leading to the establishment of pregnancy, remain poorly understood. In this context, Illumina's next-generation sequencing technology has been used to discover the uterine transcriptome signature that is favourable for ongoing pregnancy. More specifically, the present report documents on a retrospective in vivo study in which data on pregnancy outcome were linked to uterine gene expression signatures on day 6 (bovine model). Using the RNA-Seq method, 14.654 reference genes were effect

SUBMITTER: Van Hoeck V 

PROVIDER: S-EPMC4584001 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature