A Meta-analysis of the Association of Estimated GFR, Albuminuria, Age, Race, and Sex With Acute Kidney Injury.

ABSTRACT:

Background

Acute kidney injury (AKI) is a serious global public health problem. We aimed to quantify the risk of AKI associated with estimated glomerular filtration rate (eGFR), albuminuria (albumin-creatinine ratio [ACR]), age, sex, and race (African American and white).

Study design

Collaborative meta-analysis.

Setting & population

8 general-population cohorts (1,285,049 participants) and 5 chronic kidney disease (CKD) cohorts (79,519 participants).

Selection criteria for studies

Available eGFR, ACR, and 50 or more AKI events.

Predictors

Age, sex, race, eGFR, urine ACR, and interactions.

Outcome

Hospitalized with or for AKI, using Cox proportional hazards models to estimate HRs of AKI and random-effects meta-analysis to pool results.

Results<

SUBMITTER: Grams ME 

PROVIDER: S-EPMC4584180 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature