Ontology highlight
ABSTRACT:
SUBMITTER: Weissman BP
PROVIDER: S-EPMC4584197 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Biochimica et biophysica acta 20150327 11
Experimental analysis of kinetic isotope effects represents an extremely powerful approach for gaining information about the transition state structure of complex reactions not available through other methodologies. The implementation of this approach to the study of nucleic acid chemistry requires the synthesis of nucleobases and nucleotides enriched for heavy isotopes at specific positions. In this review, we highlight current approaches to the synthesis of nucleic acids enriched site specific ...[more]