Temporal trends in TB notification rates during ART scale-up in Cape Town: an ecological analysis.

ABSTRACT:

Introduction

Although antiretroviral therapy (ART) reduces individual tuberculosis (TB) risk by two-thirds, the population-level impact remains uncertain. Cape Town reports high TB notification rates associated with endemic HIV. We examined population trends in TB notification rates during a 10-year period of expanding ART.

Methods

Annual Cape Town TB notifications were used as numerators and mid-year Cape Town populations as denominators. HIV-stratified population was calculated using overall HIV prevalence estimates from the Actuarial Society of South Africa AIDS and Demographic model. ART provision numbers from Western Cape government reports were used to calculate overall ART coverage. We calculated rates per 100,000 population over time, overall and stratified by HIV st

SUBMITTER: Hermans S 

PROVIDER: S-EPMC4584214 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature