Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA.

ABSTRACT: It is increasingly recognised that lncRNAs play essential regulatory roles in fundamental biological processes and, consequently, that their dysregulation may contribute to major human diseases, including cancer. Better understanding of lncRNA biology may therefore offer new insights into pathogenetic mechanisms and thereby offer novel opportunities for diagnosis and therapy. Of particular interest in this regard is GAS5 lncRNA, which is down-regulated in multiple cancers, with expression levels related to both clinico-pathological characteristics and patient prognosis. Functional studies have further shown that GAS5 lncRNA both inhibits the proliferation and promotes the apoptosis of multiple cell types, and that together these cellular mechanisms of action are likely to form the basis of

SUBMITTER: Pickard MR 

PROVIDER: S-EPMC4584312 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature