Relation between ADIPOQ Gene Polymorphisms and Type 2 Diabetes.

ABSTRACT:

Objective

The manuscript investigates the relation between adiponectin gene (ADIPOQ) polymorphisms and type 2 diabetes mellitus (T2DM) in a Chinese population.

Methods

We designed a case-control study involving 340 normal glucose tolerant (NGT) subjects and 340 type 2 diabetes patients. Three SNPs (rs182052, rs1501299, and rs7627128) were genotyped by TaqMan methods.

Results

We found that rs7627128, rs1501299 and rs182052 were significantly associated with T2DM. Haplotypes analysis indicated that the frequency of the haplotypes A-A-T was frequent in T2DM patients (OR = 2.10; 95%CI: 1.44-2.90; p < 0.001), but G-A-T was more frequent in the control group than in the T2DM group (OR = 0.66; 95%CI: 0.54-0.81; p < 0.001).

Conclusion

The ADIPOQ genetic polymorphisms w

SUBMITTER: Li ZP 

PROVIDER: S-EPMC4584314 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature