The Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer Cells.

ABSTRACT: Lymphocyte signaling cascades responsible for anti-tumor cytotoxicity and inflammatory cytokine production must be tightly regulated in order to control an immune response. Disruption of these cascades can cause immune suppression as seen in a tumor microenvironment, and loss of signaling integrity can lead to autoimmunity and other forms of host-tissue damage. Therefore, understanding the distinct signaling events that exclusively control specific effector functions of "killer" lymphocytes (T and NK cells) is critical for understanding disease progression and formulating successful immunotherapy. Elucidation of divergent signaling pathways involved in receptor-mediated activation has provided insights into the independent regulation of cytotoxicity and cytokine production in lymphocytes.

SUBMITTER: Gerbec ZJ 

PROVIDER: S-EPMC4584950 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature