Ethnicity and Smoking-Associated DNA Methylation Changes at HIV Co-Receptor GPR15.

ABSTRACT: Smoking is associated with poorer health outcomes for both African and European Americans. In order to better understand whether ethnic-specific genetic variation may underlie some of these differences, we compared the smoking-associated genome-wide methylation signatures of African Americans with those of European Americans, and followed up this analysis with a focused examination of the most ethnically divergent locus, cg19859270, at the GPR15 gene. We examined the association of methylation at this locus to the rs2230344 SNP and GPR15 gene and protein expression. Consistent with prior analyses, AHRR residue cg05575921 was the most differentially methylated residue in both African Americans and European Americans. However, the second most differentially methylated locus in African Americ

SUBMITTER: Dogan MV 

PROVIDER: S-EPMC4585036 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature