Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure.

ABSTRACT: Methamphetamine (MA) consumption causes disruption of many biological rhythms including the sleep-wake cycle. This circadian effect is seen shortly following MA exposure and later in life following developmental MA exposure. MA phase shifts, entrains the circadian clock and can also alter the entraining effect of light by currently unknown mechanisms. We analyzed and compared immunoreactivity of the immediate early gene c-Fos, a marker of neuronal activity, to assess neuronal activation 2 h following MA exposure in the light and dark phases. We used network analyses of correlation patterns derived from global brain immunoreactivity patterns of c-Fos, to infer functional connectivity between brain regions. There were five distinct patterns of neuronal activation. In several brain areas, neu

SUBMITTER: Zuloaga DG 

PROVIDER: S-EPMC4585047 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature