The similarity between N-terminal targeting signals for protein import into different organelles and its evolutionary relevance.

ABSTRACT: The proper distribution of proteins between the cytosol and various membrane-bound compartments is crucial for the functionality of eukaryotic cells. This requires the cooperation between protein transport machineries that translocate diverse proteins from the cytosol into these compartments and targeting signal(s) encoded within the primary sequence of these proteins that define their cellular destination. The mechanisms exerting protein translocation differ remarkably between the compartments, but the predominant targeting signals for mitochondria, chloroplasts and the ER share the N-terminal position, an α-helical structural element and the removal from the core protein by intraorganellar cleavage. Interestingly, similar properties have been described for the peroxisomal targeting signa

SUBMITTER: Kunze M 

PROVIDER: S-EPMC4585086 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature