Yersinia pestis and Yersinia pseudotuberculosis infection: a regulatory RNA perspective.

ABSTRACT: Yersinia pestis, responsible for causing fulminant plague, has evolved clonally from the enteric pathogen, Y. pseudotuberculosis, which in contrast, causes a relatively benign enteric illness. An ~97% nucleotide identity over 75% of their shared protein coding genes is maintained between these two pathogens, leaving much conjecture regarding the molecular determinants responsible for producing these vastly different disease etiologies, host preferences and transmission routes. One idea is that coordinated production of distinct factors required for host adaptation and virulence in response to specific environmental cues could contribute to the distinct pathogenicity distinguishing these two species. Small non-coding RNAs that direct posttranscriptional regulation have recently been identif

SUBMITTER: Martinez-Chavarria LC 

PROVIDER: S-EPMC4585118 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature