Protein Citrullination: A Proposed Mechanism for Pathology in Traumatic Brain Injury.

ABSTRACT: Protein citrullination is a calcium-driven post-translational modification proposed to play a causative role in the neurodegenerative disorders of Alzheimer's disease, multiple sclerosis (MS), and prion disease. Citrullination can result in the formation of antigenic epitopes that underlie pathogenic autoimmune responses. This phenomenon, which is best understood in rheumatoid arthritis, may play a role in the chronic dysfunction following traumatic brain injury (TBI). Despite substantial evidence of aberrations in calcium signaling following TBI, there is little understanding of how TBI alters citrullination in the brain. The present investigation addressed this gap by examining the effects of TBI on the distribution of protein citrullination and on the specific cell types involved. Immun

SUBMITTER: Lazarus RC 

PROVIDER: S-EPMC4585288 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature