A comprehensive study on different modelling approaches to predict platelet deposition rates in a perfusion chamber.

ABSTRACT: Thrombus formation is a multiscale phenomenon triggered by platelet deposition over a protrombotic surface (eg. a ruptured atherosclerotic plaque). Despite the medical urgency for computational tools that aid in the early diagnosis of thrombotic events, the integration of computational models of thrombus formation at different scales requires a comprehensive understanding of the role and limitation of each modelling approach. We propose three different modelling approaches to predict platelet deposition. Specifically, we consider measurements of platelet deposition under blood flow conditions in a perfusion chamber for different time periods (3, 5, 10, 20 and 30 minutes) at shear rates of 212 s(-1), 1390 s(-1) and 1690 s(-1). Our modelling approaches are: i) a model based on the mass-trans

SUBMITTER: Pallares J 

PROVIDER: S-EPMC4585733 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature