Dataset Information
Enterovirus 71 2C Protein Inhibits NF-?B Activation by Binding to RelA(p65).
Ontology highlight
ABSTRACT:
SUBMITTER: Du H
PROVIDER: S-EPMC4585786 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Enterovirus 71 2C Protein Inhibits NF-κB Activation by Binding to RelA(p65).
Scientific reports 20150923
Viruses evolve multiple ways to interfere with NF-κB signaling, a key regulator of innate and adaptive immunity. Enterovirus 71 (EV71) is one of primary pathogens that cause hand-foot-mouth disease. Here, we identify RelA(p65) as a novel binding partner for EV71 2C protein from yeast two-hybrid screen. By interaction with IPT domain of p65, 2C reduces the formation of heterodimer p65/p50, the predominant form of NF-κB. We also show that picornavirus 2C family proteins inhibit NF-κB activation an ...[more]
