High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations.

ABSTRACT: Drug resistance in Plasmodium parasites is a constant threat. Novel therapeutics, especially new drug combinations, must be identified at a faster rate. In response to the urgent need for new antimalarial drug combinations we screened a large collection of approved and investigational drugs, tested 13,910 drug pairs, and identified many promising antimalarial drug combinations. The activity of known antimalarial drug regimens was confirmed and a myriad of new classes of positively interacting drug pairings were discovered. Network and clustering analyses reinforced established mechanistic relationships for known drug combinations and identified several novel mechanistic hypotheses. From eleven screens comprising >4,600 combinations per parasite strain (including duplicates) we further inve

SUBMITTER: Mott BT 

PROVIDER: S-EPMC4585899 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature