Dynamic expression of chromatin modifiers during developmental transitions in mouse preimplantation embryos.

ABSTRACT: During mouse preimplantation development, major changes in cell fate are accompanied by extensive alterations of gene expression programs. Embryos first transition from a maternal to zygotic program and subsequently specify the pluripotent and the trophectodermal cell lineages. These processes are regulated by key transcription factors, likely in cooperation with chromatin modifiers that control histone and DNA methylation. To characterize the spatiotemporal expression of chromatin modifiers in relation to developmental transitions, we performed gene expression profiling of 156 genes in individual oocytes and single blastomeres of developing mouse embryos until the blastocyst stage. More than half of the chromatin modifiers displayed either maternal or zygotic expression. We also detected

SUBMITTER: Nestorov P 

PROVIDER: S-EPMC4585904 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature