Ontology highlight
ABSTRACT:
SUBMITTER: Nishida K
PROVIDER: S-EPMC4585989 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Nishida Kento K Watanabe Hiroshi H Ogaki Shigeru S Kodama Azusa A Tanaka Ryota R Imafuku Tadashi T Ishima Yu Y Chuang Victor Tuan Giam VT Toyoda Masao M Kondoh Masumi M Wu Qiong Q Fukagawa Masafumi M Fukagawa Masafumi M Otagiri Masaki M Maruyama Toru T
Scientific reports 20150928
Rhabdomyolysis-associated acute kidney injury (AKI) is a serious life-threatening condition. As such, more effective strategies are needed for its prevention. Thioredoxin-1 (Trx), a redox-active and macrophage migration inhibitory factor (MIF) modulating protein, has a short retention time in the blood. We examined the renoprotective effect of long acting Trx that was genetically fused with human serum albumin (HSA-Trx) against glycerol-induced AKI. An intravenous HSA-Trx pre-treatment attenuate ...[more]