TrkB/BDNF signalling patterns the sympathetic nervous system.

ABSTRACT: The sympathetic nervous system is essential for maintaining mammalian homeostasis. How this intricately connected network, composed of preganglionic neurons that reside in the spinal cord and post-ganglionic neurons that comprise a chain of vertebral sympathetic ganglia, arises developmentally is incompletely understood. This problem is especially complex given the vertebral chain of sympathetic ganglia derive secondarily from the dorsal migration of 'primary' sympathetic ganglia that are initially located several hundred microns ventrally from their future pre-synaptic partners. Here we report that the dorsal migration of discrete ganglia is not a simple migration of individual cells but a much more carefully choreographed process that is mediated by extensive interactions of pre-and post

SUBMITTER: Kasemeier-Kulesa JC 

PROVIDER: S-EPMC4586040 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature