Biomarkers and mortality in severe Chagas cardiomyopathy.

ABSTRACT:

Background

Chagas cardiomyopathy is a chronic sequela of infection by the parasite, Trypanosoma cruzi. Advanced cardiomyopathy is associated with a high mortality rate, and clinical characteristics have been used to predict mortality risk. Though multiple biomarkers have been associated with Chagas cardiomyopathy, it is unknown how these are related to survival.

Objectives

This study aimed to identify biomarkers associated with mortality in individuals with severe Chagas cardiomyopathy in an urban Bolivian hospital.

Methods

The population included individuals with and without T. cruzi infection recruited in an urban hospital in Santa Cruz, Bolivia. Baseline characteristics, electrocardiogram findings, medications, and serum cardiac biomarker levels (B-type natriuretic

SUBMITTER: Sherbuk JE 

PROVIDER: S-EPMC4586047 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature