A GWAS Study on Liver Function Test Using eMERGE Network Participants.

ABSTRACT:

Introduction

Liver enzyme levels and total serum bilirubin are under genetic control and in recent years genome-wide population-based association studies have identified different susceptibility loci for these traits. We conducted a genome-wide association study in European ancestry participants from the Electronic Medical Records and Genomics (eMERGE) Network dataset of patient medical records with available genotyping data in order to identify genetic contributors to variability in serum bilirubin levels and other liver function tests and to compare the effects between adult and pediatric populations.

Methods

The process of whole genome imputation of eMERGE samples with standard quality control measures have been described previously. After removing missing data and outlie

SUBMITTER: Namjou B 

PROVIDER: S-EPMC4586138 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature