Impact of DNA polymorphisms in key DNA base excision repair proteins on cancer risk.

ABSTRACT: Genetic variation in DNA repair genes can modulate DNA repair capacity and may be related to cancer risk. However, study findings have been inconsistent. Inheritance of variant DNA repair genes is believed to influence individual susceptibility to the development of environmental cancer. Reliable knowledge on which the base excision repair (BER) sequence variants are associated with cancer risk would help elucidate the mechanism of cancer. Given that most of the previous studies had inadequate statistical power, we have conducted a systematic review on sequence variants in three important BER proteins. Here, we review published studies on the association between polymorphism in candidate BER genes and cancer risk. We focused on three key BER genes: 8-oxoguanine DNA glycosylase (OGG1), apur

SUBMITTER: Karahalil B 

PROVIDER: S-EPMC4586256 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature