Dose Response of MARV/Angola Infection in Cynomolgus Macaques following IM or Aerosol Exposure.

ABSTRACT: Marburg virus infection in humans causes a hemorrhagic disease with a high case fatality rate. Countermeasure development requires the use of well-characterized animal models that mimic human disease. To further characterize the cynomolgus macaque model of MARV/Angola, two independent dose response studies were performed using the intramuscular or aerosol routes of exposure. All animals succumbed at the lowest target dose; therefore, a dose effect could not be determined. For intramuscular-exposed animals, 100 PFU was the first target dose that was not significantly different than higher target doses in terms of time to disposition, clinical pathology, and histopathology. Although a significant difference was not observed between aerosol-exposed animals in the 10 PFU and 100 PFU target dos

SUBMITTER: Johnston SC 

PROVIDER: S-EPMC4586374 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature