Differential Plasma-cell evolution is linked with Dermatophagoides pteronyssinus immunotherapy response.

ABSTRACT: Allergic rhinitis is highly prevalent worldwide. Immunotherapy has been shown to control its symptoms, however, up to 30% of patients may not respond. Previous studies of the immunological mechanisms involved in allergen-immunotherapy (AIT) have focused on the humoral and T-cell response and several studies have evaluated some B-cell subpopulations during AIT and their role in immunological tolerance. However, although B and plasma-cell subpopulations are two of the most important cellular subtypes involved in allergic reactions, their relation with AIT efficacy remains unelucidated. The objective was to analyze the effects of immunotherapy on different B and plasma-cell subpopulations and whether these changes correlate with the clinical response to the treatment. Although no changes are

SUBMITTER: Fernandez TD 

PROVIDER: S-EPMC4586444 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature