Antenatal Magnesium and Cerebral Palsy in Preterm Infants.

ABSTRACT:

Objective

To evaluate the relationship of maternal antenatal magnesium sulfate (MgSO4) with neonatal cranial ultrasound abnormalities and cerebral palsy (CP).

Study design

In a randomized trial of MgSO4 or placebo in women at high risk of preterm delivery, up to 3 cranial ultrasounds were obtained in the neonatal period. Images were reviewed by at least 2 pediatric radiologists masked to treatment and other clinical conditions. Diagnoses were predefined for intraventricular hemorrhage, periventricular leukomalacia, intracerebral echolucency or echodensity, and ventriculomegaly. CP was diagnosed at 2 years of age by standardized neurologic examination.

Results

Intraventricular hemorrhage, periventricular leukomalacia, intracerebral echolucency or echodensity, and ventr

SUBMITTER: Hirtz DG 

PROVIDER: S-EPMC4587284 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature