A population-based case-control study of genetic variation in cytokine genes associated with risk of cervical and vulvar cancers.

ABSTRACT:

Objective

Persistent infection with oncogenic human papillomavirus (HPV) is known to be the necessary cause of cervical cancer and a majority of vulvar cancers. Persistent HPV infections must evade host immune responses, including cytokines released by activated T-helper (Th) cells. In this study, we investigated the risk of cervical and vulvar cancers associated with common genetic variations in 560 tagging single-nucleotide polymorphisms (SNPs) in candidate cytokine genes.

Methods

The study included 399 invasive squamous cell carcinomas (SCCs) and 502 in situ or invasive adenocarcinomas (AC) of the cervix; 357 in situ or invasive vulvar SCC; and 1109 controls from the Seattle-area case-control studies of HPV-related cancers. Logistic regression was used to estimate odds ra

SUBMITTER: Hardikar S 

PROVIDER: S-EPMC4587291 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature