Prognostic significance of differential expression of angiogenic genes in women with high-grade serous ovarian carcinoma.

ABSTRACT:

Objectives

To identify angiogenic biomarkers associated with tumor angiogenesis and clinical outcome in high-grade serous ovarian cancer (HGSC).

Methods

51 HGSC samples were analyzed using Affymetrix HG-U133A microarray. Microvessel density (MVD) counts were determined using CD31 and CD105. Associations between mRNA expression levels and overall survival were assessed using rank score statistic. Effect size was estimated as a hazard ratio (HR) under a proportional hazard model. The Storey q-value method was used to account for multiple testing within the false-discovery rate (FDR) framework. Publicly available databases including TCGA and GSE were used for external confirmation.

Results

Thirty-one angiogenic-related genes were significantly associated with survival (q

SUBMITTER: Siamakpour-Reihani S 

PROVIDER: S-EPMC4587300 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature