Proteomic Analysis of Connexin 43 Reveals Novel Interactors Related to Osteoarthritis.

ABSTRACT: We have previously reported that articular chondrocytes in tissue contain long cytoplasmic arms that physically connect two distant cells. Cell-to-cell communication occurs through connexin channels termed Gap Junction (GJ) channels, which achieve direct cellular communication by allowing the intercellular exchange of ions, small RNAs, nutrients, and second messengers. The Cx43 protein is overexpressed in several human diseases and inflammation processes and in articular cartilage from patients with osteoarthritis (OA). An increase in the level of Cx43 is known to alter gene expression, cell signaling, growth, and cell proliferation. The interaction of proteins with the C-terminal tail of connexin 43 (Cx43) directly modulates GJ-dependent and -independent functions. Here, we describe the i

SUBMITTER: Gago-Fuentes R 

PROVIDER: S-EPMC4587334 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature