Gallstone Disease and the Risk of Ischemic Heart Disease.

ABSTRACT:

Objective

Gallstone disease (GSD) is related to multiple cardiovascular risk factors; the present study was to prospectively examine the association between GSD and ischemic heart disease (IHD).

Approach and results

We examined the association of GSD with IHD among 199 292 men and 288 081 women aged 30-79 years in the China Kadoorie Biobank study. Participants with cancer, heart disease, and stroke at baseline were excluded. Cox proportional hazards regression model was used to estimate the association of GSD with IHD. The prevalence of self-reported GSD was 3.7% in men and 7.3% in women at baseline. During 3 431 124 person-years of follow-up between 2004 and 2013 (median, 7.2 years), we documented 10 245 incident IHD cases in men and 14 714 in women. As compared with men wi

SUBMITTER: Lv J 

PROVIDER: S-EPMC4587542 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature