Volatile Biomarkers in Breath Associated With Liver Cirrhosis - Comparisons of Pre- and Post-liver Transplant Breath Samples.

ABSTRACT:

Background

The burden of liver disease in the UK has risen dramatically and there is a need for improved diagnostics.

Aims

To determine which breath volatiles are associated with the cirrhotic liver and hence diagnostically useful.

Methods

A two-stage biomarker discovery procedure was used. Alveolar breath samples of 31 patients with cirrhosis and 30 healthy controls were mass spectrometrically analysed and compared (stage 1). 12 of these patients had their breath analysed after liver transplant (stage 2). Five patients were followed longitudinally as in-patients in the post-transplant period.

Results

Seven volatiles were elevated in the breath of patients versus controls. Of these, five showed statistically significant decrease post-transplant: limonene, metha

SUBMITTER: Fernandez Del Rio R 

PROVIDER: S-EPMC4588000 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature