Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and trafficking.

ABSTRACT: A proper balance between chemical reduction and oxidation (known as redox balance) is essential for normal cellular physiology. Deregulation in the production of oxidative species leads to DNA damage, lipid peroxidation and aberrant post-translational modification of proteins, which in most cases induces injury, cell death and disease. However, physiological concentrations of oxidative species are necessary to support important cell functions, such as chemotaxis, hormone synthesis, immune response, cytoskeletal remodeling, Ca(2+) homeostasis and others. Recent evidence suggests that redox balance regulates actin and microtubule dynamics in both physiological and pathological contexts. Microtubules and actin microfilaments contain certain amino acid residues that are susceptible to oxidatio

SUBMITTER: Wilson C 

PROVIDER: S-EPMC4588006 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature