Antifungal Activity of 14-Helical β-Peptides against Planktonic Cells and Biofilms of Candida Species.

ABSTRACT: Candida albicans is the most prevalent cause of fungal infections and treatment is further complicated by the formation of drug resistant biofilms, often on the surfaces of implanted medical devices. In recent years, the incidence of fungal infections by other pathogenic Candida species such as C. glabrata, C. parapsilosis and C. tropicalis has increased. Amphiphilic, helical β-peptide structural mimetics of natural antimicrobial α-peptides have been shown to exhibit specific planktonic antifungal and anti-biofilm formation activity against C. albicans in vitro. Here, we demonstrate that β-peptides are also active against clinically isolated and drug resistant strains of C. albicans and against other opportunistic Candida spp. Different Candida species were susceptible to β-peptides to var

SUBMITTER: Raman N 

PROVIDER: S-EPMC4588179 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature