Integrative Modeling of Macromolecular Assemblies from Low to Near-Atomic Resolution.

ABSTRACT: While conventional high-resolution techniques in structural biology are challenged by the size and flexibility of many biological assemblies, recent advances in low-resolution techniques such as cryo-electron microscopy (cryo-EM) and small angle X-ray scattering (SAXS) have opened up new avenues to define the structures of such assemblies. By systematically combining various sources of structural, biochemical and biophysical information, integrative modeling approaches aim to provide a unified structural description of such assemblies, starting from high-resolution structures of the individual components and integrating all available information from low-resolution experimental methods. In this review, we describe integrative modeling approaches, which use complementary data from either cr

SUBMITTER: Xu X 

PROVIDER: S-EPMC4588362 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature