The extracellular matrix modulates H2O2 degradation and redox signaling in endothelial cells.

ABSTRACT: The molecular processes that are crucial for cell function, such as proliferation, migration and survival, are regulated by hydrogen peroxide (H2O2). Although environmental cues, such as growth factors, regulate redox signaling, it was still unknown whether the ECM, a component of the cell microenvironment, had a function in this process. Here, we showed that the extracellular matrix (ECM) differently regulated H2O2 consumption by endothelial cells and that this effect was not general for all types of cells. The analysis of biophysical properties of the endothelial cell membrane suggested that this modification in H2O2 consumption rates was not due to altered membrane permeability. Instead, we found that the ECM regulated GPx activity, a known H2O2 scavenger. Finally, we showed that the ex

SUBMITTER: Bagulho A 

PROVIDER: S-EPMC4588420 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature