Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment.

ABSTRACT:

Objective

Macrophage accumulation in adipose tissue (AT) during obesity contributes to inflammation and insulin resistance. Recruitment of monocytes to obese AT has been the most studied mechanism explaining this accumulation. However, recent evidence suggests that recruitment-independent mechanisms may also regulate pro-inflammatory AT macrophage (ATM) numbers. The role of increased ATM survival during obesity has yet to be explored.

Results

We demonstrate that activation of apoptotic pathways is significantly reduced in ATMs from diet-induced and genetically obese mice. Concurrently, pro-survival Bcl-2 family member protein levels and localization to the mitochondria is elevated in ATMs from obese mice. This increased pro-survival signaling was associated with elevated act

SUBMITTER: Hill AA 

PROVIDER: S-EPMC4588436 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature