Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons.

ABSTRACT: OBJECTIVE:Leptin modulates food reward via central leptin receptor (LepRb) expressing neurons. Food reward requires stimulation of midbrain dopamine neurons and is modulated by central leptin action, but the exact central mechanisms remain unclear. Stimulatory and inhibitory leptin actions on dopamine neurons have been reported, e.g. by indirect actions on orexin neurons or via direct innervation of dopamine neurons in the ventral tegmental area. METHODS:We showed earlier that LepRb neurons in the lateral hypothalamus (LHA) co-express the inhibitory acting neuropeptide galanin (GAL-LepRb neurons). We studied the involvement of GAL-LepRb neurons to regulate nutrient reward in mice with selective LepRb deletion from galanin neurons (GAL-LepRb(KO) mice). RESULTS:We found that the rewarding va

SUBMITTER: Laque A 

PROVIDER: S-EPMC4588437 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature